1.0 INTRODUCTION

Carica papaya belongs to the family of Caricaceae, and several species of Caricaceae have been used as remedy against a variety of diseases (Alabi et al., 2012). Carica papaya is a neutraceutical plant having a wide range of pharmacological activities. The whole plant has its own medicinal value. Papaya is a powerhouse of nutrients and is available throughout the year. It is a rich source of threes powerful antioxidant vitamin C, vitamin A and vitamin E; the minerals, magnesium and potassium; the B vitamin pantothenic acid and folate and fiber (Aravind et al., 2013). The black seeds of the papaya are edible and have a sharp, spicy taste. They are sometimes ground and used as a substitute for black pepper. Dried papaya seeds actually look quite similar to peppercorns and can be used in just the same way. Sprinkle a little quantity over a meal, especially protein rich meals, is a simple way to add extra enzymes to your diet and improve your digestive appetite. The papaya seeds are very pungent and peppery, making them almost unpalatable. However the seeds seem to have more potent medicinal values than the flesh. Papaya seeds have antibacterial properties and are effective against Escherichia coli, Salmonella and Staphylococcus infections. Papaya seeds may protect the kidneys from toxin induced kidney failure. Papaya can eliminate intestinal parasites. It is used as heamoroid Cure for (piles) and typhoid and anti-helminthic and anti-amoebic properties (Aravind et al., 2013).

Enteric bacteria naturally live in the intestine of animals and humans; however some of these bacteria cause diarrhoea. Diarrhoea disease is one of the   leading   cause of illness in young children in Nigeria (Parashar et al; 2013). Diarrhoea disease are the cause of almost three million deaths annually mainly among children younger than five years of age, (Seung-Hak et al., 2006). Available report in Nigeria indicates that more than 315,000 deaths of pre-school age children are recorded annually as a result of diarrhoea disease (Babaniyi et al., 1991; Alabi et al; 1998).  

 The seed of papaya has antimicrobial activity against Trichomonas vaginali strophozoites. It could also be used in urinogenital disorder like trichomoniasis with care to avoid toxicity. The seeds, irrespective of its fruit maturity stages have bacteriostatic activity on gram positive and negative organisms which could be useful in treating chronic skin ulcer. However, little information exits on the antimicrobial property of Carica papaya dried and fresh leaves (Alabi et al., 2012). Recently, antifertility (Lohiya et al., 1999) antihelminthic (Satrija et al., 1995) and anti-inflammatory activity (Osho et al., 2007) have been reported. Carica papaya seeds possess moisture, proteins, fatty acids, and phospholipids, such as phosphotidylcholine and cardiolipin. Other compounds present in seeds are c farpaine, benzyl isothiocynate, benzyl glucosinolate, beta-sitosterol,caricin, enzyme myrosin. The well-studied proteinases from papaya are papain, chymopapain, caricain, and glycylendopeptidase. Papain occurs in all parts of the tree except the root (Anonymous, 1992).