ANTIBACTERIAL ACTIVITY OF THREE TYPES OF MEDICATED SOAPS OF STARHYROCOCCUS AUREUS FORM WOUND INFECTIONS

Code No: 510825

₦5,000.00

ABSTRACT

The antibacterial activity of three type of medicate soap on staphylococcus aureus isolated from wound infections was conducted. Fifty individual with would infection within the age range of 9-73 years were sampled. Swabsticks were used to collect specimens from wound infection. each swabstick was streaked separately over plates of nutrient and macconkey agar and later incubated at 370c. out of the fifty (50) individuals sampled 25(50%) were mostly infected with staphylococcus aureus followed by pseudomonas acruginqu (22%) staphylococcus epidermis (10%) least by Exchericha coli b(12%) The organisms occur within the age range 9-13 years with 8 (16%) followed by 14-18 years 4(8%) next by the age range of 19-23 years 3(6%) followed by 24-28 years with 2(4%) followed 24-28 years with 2(4%) and the heart in the age range are 29-33,34-38,39-43,44-48,49-53,54-58 64-68 with 1(2%) each while there was no isolation in the age range 59-63. The study also revealed that all the staphylococcus aureus isolated were sensitive to the three medicated soap. The means of inhibition was highest in Aleppo medicated soap with 12.92 mm followed by temperate medicated soap with 11.2mm and least in carat medicated soap with 10.56 mm. Also the staphylococcus aureus isolated were also sensitive to the commercial autibutics used as couplers the means zones of inhibition was highest in ampiclox with 12.8 mm followed by gentamyain with 12.04 mm and the heart in penicillin with 10.4 mm. there was a close relationship in the zenes of inhibition between the three medicated soap and the commercial antibiotics used as coconutrels. The result showned that medicated soaps were effective against staphylococcus aureus involved in would infection in humans and are comparable to commercial antibiotics. There fore medicated soap can be used in cleaning the skin particularly in the affected part of the skin during the time one has hurt or cut on the skin.

CHAPTER 1

CHAPTER ONE
INTRODUCTION
According to pelage et al (1986) antibacterial activity is the ability to either destroy bacteria or inhibit their growth. This is significant with respects to the human body in preventing sepsis and skin infections. Also Derland (1981) states that medicated soap have the germicidal substance like chloroxyhlenol potassium mercuric iodide, trichlorocarbanlide etc. incorporated into them, in order to enhance their antibacterial activity. These germicide substance are normally added in a specified amount and percentage of the substance used are always stated on the soapcase or inside the lesflet which certains the information on how to use the soap for various purposes.
Anon (1964) states that soap may be defined as a chemical compound resulting from the interaction of fathy acids oil and caustic soda (alkali) possesing the characteristic soap like properties of detergents, surface tension lowering wetting and emulsifying power and gel formation. All fatty oils and fats. Are mixtures of glycoside compounds (erters) of trihydric alcohol, glycosides and some fatty acids such as plasmatic acid the chemistry of soap manufacturing may be expressed the following equation which is know as saponification (Anon (1964).
HzCocoG5H31)3 + Na 0H Naoco15H31 (zH31 + c3H5(oH)3
Palliation caustic sodium palurtate glycerion
Soda
Amon (1964) further explain that a bactericidal soap cernirts existentially of the following 0.1 to 3% weight based on the total weight of the soap.
0 to 10% by weight based on the total weight of the soap in a compound of formular
R â€“Co-N1-CH2C00H
CH3
Here R represents an alkyl or alkenye group of 8 to carbon atoms.
According to Johnson (1978) antibacterial soap may include 2,4,4,trichloro 2,2 hydroxydiphenyl in an amount 0.05 to 5% by weight and at least one phosphorus oxyacid. Phosphorus oxyacid salt phosphoric ester is represented by
(R1(oCH,CH2)
R2
Where R1 in (8-20 alkyl, R2 is hydrogen or methyl and is (1-10). R1 is the same group as R2 or H alkali metal and n is H or alkali metal. Such a soap has a wide range of antibacterial activities and marked resistance of discoloration upon exposure to sunlight (Kaw,1981) another invention relates to an autimicrobial composition consisting of ammoniated zinc sulphate optionally formulated into sufficient formulation and toilet bars. Medicated soap incorporate in their composition germicidal agent which include hexachlorophene mercuric which trichoran, trichlorocarbaucide .